Managing COVID-19 symptoms and post-vaccination symptoms with paracetamol

24 February 2022
covid
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UNI-PHARMA

Important information

Paracetamol has more than 60 years of history as a first-line treatment for fever and mild to moderate pain, but what are the guidelines for its use during the COVID-19 pandemic?

We have drawn together guidance from health authorities, giving you all the information you need on COVID-19 and paracetamol in one place.

Managing COVID-19 symptoms

Paracetamol is recommended by public health authorities as part of the symptomatic treatment of COVID-19. Patients presenting symptoms of COVID-19 infection should seek appropriate medical advice and follow guidelines issued by the competent authorities. Read more from the World Health Organisation and European Medicines Agency.

Use of paracetamol after COVID-19 vaccination

Health authorities around the world recommend the use of paracetamol to treat fever and mild pain symptoms following vaccination. Read more from the CDC.

General paracetamol advice

You should always read the patient information leaflet before use and you should never take more than one paracetamol-containing product at one time. You should always use the lowest dose and shortest duration of paracetamol needed to effectively relieve their symptoms. Contact your doctor or pharmacist if in any question or doubt.

Q & A

  • Is paracetamol effective in treating COVID-19?

    No, paracetamol does not treat COVID-19, however appropriate use of paracetamol is currently being recommended by public health authorities, including the World Health Organisation, as part of the symptomatic treatment of COVID-19, to reduce fever and provide relief from mild to moderate pain1. Paracetamol is a well-established treatment for fever reduction and mild to moderate pain relief in adults and children. It has been available for more than 60 years and is used by millions of patients worldwide.

  • Can I use products containing paracetamol for COVID-19?

    Paracetamol does not treat COVID-19, however appropriate use of paracetamol is currently being recommended by public health authorities, including the World Health Organisation, as part of the symptomatic treatment of COVID-19, to reduce fever and provide relief from mild to moderate pain1. You should always read the patient information leaflet before use and you should never take more than one paracetamol-containing product at the same time. You should use the lowest dose needed for the shortest period of time to control symptoms. Contact your doctor or pharmacist if in any question or doubt.

  • Should I take paracetamol instead of ibuprofen to treat COVID-19?

    Neither paracetamol nor ibuprofen treat COVID-19, but both can be helpful in managing the fever and pain that some patients might experience with the disease. Appropriate use of ibuprofen and paracetamol is currently being recommended by most public health authorities as part of the symptomatic treatment of COVID-19, to reduce fever and provide relief from mild to moderate pain1. You should always read the patient information leaflet before use and you should never take more than one paracetamol-containing product at one time. You should always use the lowest dose and shortest duration of paracetamol needed to effectively relieve their symptoms. Contact your doctor or pharmacist if in any question or doubt.

  • Can children take paracetamol for COVID-19?

    Paracetamol is a well-established treatment for fever reduction and mild to moderate pain relief in adults and children. Appropriate use of paracetamol is currently being recommended by public health authorities, including the World Health Organisation, as part of the symptomatic treatment of COVID-19, to reduce fever and to provide relief from mild to moderate pain. You should always read the patient information leaflet before use and children should never take more than one paracetamol-containing product at one time. Children should always use the lowest dose and shortest duration of paracetamol needed to effectively relieve their symptoms. Contact your doctor or pharmacist if in any question or doubt.

  • Can I take paracetamol to relieve symptoms following COVID-19 vaccination?

    You should carefully follow the post-vaccination instructions provided by the healthcare professional at the time of vaccination, including any recommendations about the use of paracetamol to relieve pain and fever symptoms that they might experience following vaccination. The appropriate use of paracetamol is recommended by public health authorities to help relieve mild pain and fever symptoms that may be experienced following vaccination2. Contact your doctor or pharmacist if in any question or doubt.

  • Should I be concerned about taking paracetamol following COVID-19 vaccination?

    You should carefully follow the post-vaccination instructions provided by the healthcare professional at the time of vaccination, including any recommendations about the use of paracetamol to relieve pain and fever symptoms that you might experience following vaccination. Contact your doctor or pharmacist if in any question or doubt. After any vaccination injection, you may experience localised pain in the days following, as well as other symptoms, such as headache, fever, and myalgia that can cause substantial discomfort6. he appropriate use of medicines such as paracetamol to relieve pain and fever symptoms sometimes experienced following vaccination is well documented3-5 , and public health authorities recommend appropriate use of paracetamol to treat these symptoms following COVID-19 vaccination2.

  • Does paracetamol blunt the immune response to the COVID-19 vaccine?

    If you are already taking paracetamol to manage pain or fever symptoms should consult a healthcare professional ahead of any planned vaccination. Currently, public health authorities have not published any evidence that suggests that the use of paracetamol to manage fever and pain prior to receiving the COVID-19 vaccine has an impact on the immune response post-vaccination. After any vaccination injection, you may experience localised pain in the days following, and other symptoms, such as headache, fever, and myalgia that can cause substantial discomfort6. The appropriate use of paracetamol is recommended by public health authorities, to help relieve pain and fever symptoms that may be experienced following COVID-19 vaccination2. You should carefully follow the post-vaccination instructions provided by the healthcare professional at the time of vaccination, including any recommendations about the use of paracetamol to relieve pain and fever symptoms that some individuals might experience following a COVID-19 vaccination. Contact your doctor or pharmacist if in any question or doubt.

  • Can I take paracetamol before the COVID-19 vaccination to help prevent pain or fever that may get as a result?

    It is not yet recommended for public health authorities to take paracetamol, or any other analgesic, as a precautionary measure to treat the symptoms of pain and fever that may occur after vaccination5. The appropriate use of paracetamol is recommended by public health authorities to help relieve mild pain and fever symptoms that may be experienced following vaccination2,5. Contact your doctor or pharmacist if in any question or doubt.


1. WHO. Home care for patients with suspected or confirmed COVID-19 and management of their contacts. Interim guidance, 13 August 2020. Available at https://apps.who.int/iris/rest/bitstreams/1292529/retrieve. Last accessed 30 September 2020.
2. CDC. What to expect after getting a COVID-19 vaccine. Available at: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/expect/after.html. Last accessed 21 December 2020.
3. Immunization action coalition. Medical management of vaccine reactions in adults in a community setting. Available at: https://www.immunize.org/catg.d/p3082.pdf Last accessed 21 December 2020.
4. Aoki FY, et al.Effects of acetaminophen on adverse effects of influenza vaccination in health care workers. CMAJ. 1993 Nov 15; 149(10): 1425–1430.
5. CDC. General best practice guidelines for immunization (advisory committee on immunization practices, ACIP). Available at: https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/downloads/general-recs.pdf. Last accessed 21 December 2020.
6. Herve C, et al. The how’s and what’s of vaccine reactogenicity. NPJ vaccines. 2019. 4, 39. Available at: https://doi.org/10.1038/s41541-019-0132-6.